Electron 26.2.1 instal the new for windows

Importantly, our array-level data qualitatively captured the static fluorescence image of the cells and the intracellular Ca 2+ dynamics, both of which are correlated with the microscope-collected data. Employing fluorescence microscopy as the reference, we demonstrate that our array can conduct on-chip Ca 2+ imaging in C2C12 cells that were chemically triggered to increase their intracellular Ca 2+ levels.

Coated with a spectral filter layer that has a high extinction ratio (>10 3), our array features high wavelength selectivity (>10 2), high linearity ( R 2 > 0.98), and low detection limit (45.1 μW 640/30 nm light). In this work, we report a 100%-yield, spectrally filtered passive Si photodiode array designed for on-chip fluorescence imaging of intracellular Ca 2+ dynamics. However, it is challenging to integrate a spectral filter onto such devices (to block the excitation light) that has similar performance to the state-of-the-art emission filters used in fluorescence microscopes. On-chip fluorescence imaging devices are recognized for their miniaturized and implantable nature that can benefit the study of intracellular dynamics at a variety of settings.

Electron 26.2.1 instal the new for windows